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Cheap priligy dapoxetine. Treatment and Outcome In the open-label phase, all patients achieved a 60-point reduction in the Beck Depression Inventory-II total score during the initial 6 months of treatment and a 63-point reduction by the month 31 visit after discontinuation of the study drug. The proportion of responders to clomipramine was higher among patients who received placebo. In the open-label phase, proportion of responders at 6 months decreased to 34% in the clomipramine group relative to 42% in the placebo group, and proportion of responders at 6 months month 31 rose to 42% in the clomipramine group versus 39% in the placebo group. In the double-blind phase, 17 of 36 patients (46%) who received clomipramine and 15 of the 36 (42%) who received placebo achieved a 60-point reduction in the Beck Depression Inventory-II total score. In the clomipramine group, 33 of 42 (85%) responded, compared with 17 of 38 (50%) the placebo group. Clomipramine Trial Design and Population Clomipramine was tested in a double-blind, parallel randomized, placebo-controlled study with a 6-week treatment period followed by 2 weeks of open-label treatment. A total 90 randomized patients aged 18 to 55 with a diagnosis of major depressive disorder were randomly assigned to receive clomipramine (n = 30) or placebo 30). The study was conducted as a single-entity, placebo-controlled, parallel-group study with a 6-week treatment period followed by 1 week of open-label treatment. Patients in the clomipramine group were treated for 18 months with the active drug, while patients in the placebo group were treated for 18 months with placebo. Intervention Clomipramine was administered at 1.5, 2, and 3 mg/day. Primary Outcome Measures A composite endpoint of 60-point reduction Beck Depression Inventory-II total score on the initial treatment visit and at 6 months was chosen to represent response treatment. The criterion is based on established criteria of the International League Against Depression in their meta-analysis of placebo-controlled trials pharmacological treatment major depression.14 Secondary outcome measures included the Hamilton Depression Rating Scale (HAM-D) and the Montgomery–Asberg Depression Rating Scale (MADRS) as measures of severity depression and the Clinical Global Impressions-Severity of Depression Scale (CGI-S) as measure of illness severity. Analysis of the Results The primary analysis of efficacy clomipramine vs placebo was performed at 6 months because the majority of patients had achieved a 60-point reduction by month 6. The intention-to-treat population in clomipramine group included patients who received placebo in the open-label phase. There were also 5 patients who received clomipramine when receiving placebo in the open-label phase. All patients who received placebo in the open-label phase were treated as outpatients in the double-blind phase. Clinical efficacy was analyzed both for intention-to-treat and per-protocol. Data were analyzed using the intention-to-treat population and per-protocol population, excluding outpatients in the double-blind phase. A significance level of.05 was employed for all analyses, including multiple comparisons among groups. The intention-to-treat population was defined as patients who had a primary depression diagnosis by the research team. In per-protocol population, patients were defined as eligible based on a clinical diagnosis recorded by research staff. In both the intention-to-treat and per-protocol analysis, missing data were imputed for the missing data at baseline and 6 months. The missing data baseline was imputed using a patient-specific imputation variable for missing data. The imputed baseline data used in the per-protocol analysis for intention-to-treat patients was used the data in per-protocol analysis for analysis. Sample Size The efficacy of clomipramine in open-label phase was compared with the efficacy of fluoxetine in a placebo-controlled, double-blind, parallel-group study that compared the effects of clomipramine with placebo. This intention-to-treat population provided a power calculation that determined how many patients needed to be enrolled compare the efficacy of clomipramine with fluoxetine in the open-label phase. Participation Patients and investigators were notified of eligibility for the study between Jan 1, 2003, and 31, 2006. No patients or investigators buy priligy pills were excluded due to eligibility. Patients were considered eligible if they met the DSM-.

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